Description
Metoclopramide is a substituted benzamide with prokinetic and antiemetic properties. It stimulates the motility of the upper gastrointestinal tract and accelerates gastric peristalsis without stimulating gastric, biliary or pancreatic secretions, leading to increased gastric emptying and intestinal transit time. It blocks dopamine receptors and serotonin receptors (at higher doses) in chemoreceptor trigger zone of the CNS.