Description
Mirtazapine, a tetracyclic antidepressant, blocks the central presynaptic α2– adrenergic autoreceptors and heteroceptors resulting in an increased noradrenergic and serotonergic activity. It also has a potent blocking activity in 5-HT2, 5-HT3 serotonin receptor and H1 histamine receptor while a moderate blocking activity in peripheral α1-adrenergic and muscarinic antagonist.